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Meldonium is better known as mildronate, a drug that improves metabolism and energy metabolism in tissues.

Meldonium (mildronate) was developed in 1975 by Professor Ivars Kalvins, now the head of the Department of Medicinal Chemistry of the Latvian Institute in Riga.

He was looking for a substance in the body, the resources of which are depleted during systematic overloads. The substance gamma-butyrobetaine was discovered. It was transformed for easy storage and use, so it turned out meldonium.

Complex treatment of ischemic heart disease (condition after myocardial infarction, angina pectoris), cardiac arrhythmias, intoxication with drugs of cardiac glycosides.

Treatment of cardiomyopathies of various origins, myocardial dystrophies (against the background of heavy physical exertion, infectious and endocrine genesis), myocarditis.

Treatment of liver diseases (hepatitis, liver cirrhosis, fatty liver).

Prevention of radiation leukopenia.

Improvement of visual function in open-angle glaucoma with normalized intraocular pressure.

Complex treatment of ischemic heart disease (condition after myocardial infarction, angina pectoris), cardiac arrhythmias, intoxication with drugs of cardiac glycosides.

Treatment of cardiomyopathies of various origins, myocardial dystrophies (against the background of heavy physical exertion, infectious and endocrine genesis), myocarditis.

Treatment of liver diseases (hepatitis, liver cirrhosis, fatty liver).

Prevention of radiation leukopenia.

Improvement of visual function in open-angle glaucoma with normalized intraocular pressure.

In the nervous system, ATP molecules act as a neurotransmitter, transmit a signal in purinergic synapses. At the same time, ATP is accompanied by acetylcholine and noradrenergic mediation.

With systemic administration of sodium, adenosine triphosphate-Darnitsa exhibits metabolic, antiarrhythmic action, improves cerebral and coronary blood flow. The antiarrhythmic action is related to the inhibition of the sinus node's automatism and the conduction of impulses on Purkinje fibers.

Partially blocks calcium channels and facilitates transmembrane transfer of potassium ions.

In patients with arterial hypertension, the use of the drug once a day provides a clinically meaningful reduction of blood pressure for 24 hours in the position both lying and standing. Because of the slow onset of amlodipine, acute arterial hypotension is usually not observed.

In patients with angina when applying one daily dose of the drug increases total physical activity, time to the onset of angina and time to 1 mm depression of the segment of ST. The drug reduces the incidence of angina and reduces the need for nitroglycerin.